This paper provides total factor productivity estimates for a sam- ple of 115 European Regions over the period 1976-2000. In particular, a set of Cobb-Douglas production functions is estimated using panel techniques and allowing for heterogeneity across regions. Moreover, on the basis of speci…c panel tests, the paper shows that there is em- pirical evidence which suggests the presence of unit roots in the series and panel cointegration tests are applied to guard against spurious regression.