This article analyzes, through a case study, the potential of cultural / archaeological tourism as an engine of development and intercultural dialogue in the Mediterranean marginal areas. In this scenario the role of cultural heritage and the specific routes or itineraries of cultural and tourist potential use turn fundamental in an environment of diversity in dialogue and exchange of north-south balance. The case study presented in this article refers to the experience of the project South - East Archeritage (project funded by the EU through the program ENPI-CITY) and the enhancement of the common historical heritage and knowledge derived from the persistence Roman legacy.