This study investigates the competitiveness and efficiency of Small and Medium Enterprises (SMEs) within the Cultural and Creative Industries (CCI) in Italy, using a comprehensive firm-level dataset from 2019 to 2023. We estimate Total Factor Productivity (TFP) to analyze firm performance, addressing endogeneity concerns through panel fixed-effects models and employing a Translog production function for flexible input elasticity. Our findings reveal significant spatial heterogeneity, with central and north-western regions exhibiting higher CCI productivity than southern areas. Furthermore, we uncover disparities related to firm size, age, and specialization within Creative versus Cultural domains. The largest and oldest CCI firms show a higher TFP. The Creative industry demonstrates greater productivity than the Cultural industry. We provide evidence that manufacturing-oriented CCI tend to exhibit lower productivity compared to service-oriented CCI. The results underscore the importance of targeted policies to address regional disparities and sectorspecific challenges within the CCI ecosystem, promoting innovation and sustainable growth.