We use national panel data at provincial level to investigate the relationship between suicide rates and socio-economic factors in Italy. The role of family, drug and alcohol consumption, social conformism and population density are the main factors in explaining the suicide rate in Italy. In a further step, we check for the differences in the suicide determinants between southern and northern provinces. The findings show that the number and size of families as well as alcohol or drug abuse play a key role in the northern provinces, while density and social conformism appear to be the main factors in the South.